Yes. We refer to this type of setup as a phone-to-RF base. At the phone-to-RF base, the following are needed: a CS I/O null-modem port (CH100 with A100), a power supply (BP12 or BP24), a radio (RF401), and a phone modem (COM220). Other items are likely needed, such as an enclosure (ENC12/14) and mounting hardware. The phone-to-RF base cannot include a data logger. For details, see Appendix I of the RF401 Instruction Manual.